Here's something I saw on TechNow TV today: a live performance covering New Order's Blue Monday using Guitar Hero controllers. The controllers are USB devices that act as inputs to the software developed to play notes and chords.
It reminds me of the times in high school / college when I would play around with Super Studio Session on the Mac and cover the Blue Monday intro (bass drum followed by bass line).
The band is called the Guitar Zeros, and their web site has a guide on how to use a Guitar Hero controller as an instrument. They also have a MySpace page.
Here's the video on technowtv.com with the story.